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Polymyxin B Sulfate BioChemica

Code
A0890
CAS
1405-20-5
Molecular Formula
C55H96N16O13 · 2H2SO4
Molar mass
1385.63 g/mol

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Box prices only valid with purchase of full box.

code packaging size price per unit box price per unit
Code & packaging Price per piece
A0890,0001
code
A0890,0001
packaging size
1 g
price per unit
single 39,20€
box price per unit
A0890,0005
code
A0890,0005
packaging size
5 g
price per unit
single 157,40€
box price per unit
A0890,0010
code
A0890,0010
packaging size
10 g
price per unit
single 295,70€
box price per unit
Physical Description:
Solid
Product Code:
A0890
Product Name:
Polymyxin B Sulfate BioChemica
Specifications:
Activity (dried subst.): approx. 7000 I.U./mg
pH (2 %; H2O): 5.0 - 7.0
Sulfated ash: max. 1 %
Loss on drying: max. 5 %
Sulfate: max. 17 %
Comment:
Polymyxin B was isolated from Bacillus polymyxa and is a component of the polymyxin-complex, consisting of polymxyin A-E and M. Just polymyxin B and E are of practical importance. Polymyxin B is a basic, cyclic octa- (or hepta-) peptide with a peptide side chain. It permeabilizes the bacterial cytoplasma membrane by interaction with phospholipid components. The efflux of essential components explain the bactericidal activity against non-proliferating bacteria. The bactericidal activity will be reduced by divalent ions (Fe2\+, Mn2\+, Ca2\+, Mg2\+), non-saturated fatty acids and polyphosphates. Polymyxin B is only active against proliferating and non-proliferating gram negative bacteria.Stability\: It is a faint yellow powder, stable and resistant against heat (in solutions at pH values from 2 - 7, especially 3 -5). It is inactivated in strong acidic or alkaline solutions. An aqueous solution can be stored at \+4°C for approx. 2 months (5). Polymyxin may be dissolved in water or methanol (< 25 mg/ml). It is of low solubility in organic solvents.
Bibliography:
(1)Storm, D.R. et al. (1977) Ann. Rev. Biochem. 46, 723-763Review article\: Polymyxin and related peptide antibiotics. (2)Schächtele, C. et al. (1988) Biochem. Biophys. Res. Com. 151, 542-547Stimulus-dependent inhibition of platelet aggregation by PKC-inhibitors. (3)Raynor, R.L. et al. (1991) J. Biol. Chem. 266, 2753-2758Membrane interaction of amphiphil polypeptides\: Mastoparan, Melittin, Polymyxin B. (4)Lucas, M. et al. (1994) Biochem. Pharmacol. 47, 667-672Protein kinase C activation increases the survival of mature lymphocytes. (5)Schupp, J.M. et al. (1995) BioTechniques 19, 18-20Reagent for the permeabilisation of bacteria for enzyme assays.
Hazard pictograms
  • GHS07 Hazard
WGK:
1
Storage:
RT
protected from light
Signal Word:
Attention
GHS Symbols:
GHS07
H Phrases:
H302
P Phrases:
P301+P312
EINECS:
215-774-7
CS:
29419000
Download TDS file for complete specifications