Back

Colistin Sulfate BioChemica

Code
A2922
CAS
1264-72-8
Molecular Formula
C53H104N16O21S2
Molar mass
1365.64 g/mol

Recommended prices only. To see your prices login or contact your local distributor.
Box prices only valid with purchase of full box.

code packaging size price per unit box price per unit
Code & packaging Price per piece
A2922,0001
code
A2922,0001
packaging size
1 g
price per unit
single 160,20€
box price per unit
Physical Description:
Solid
Product Code:
A2922
Product Name:
Colistin Sulfate BioChemica
Specifications:
Potency (dried subst.): min. 19000 U/mg
pH (1 %; H2O): 4.0 - 6.0
Loss on drying: max. 3.5 %
Sulfate: 16 - 18 %
Hazard pictograms
  • GHS06 Hazard
UN:
2811
Class/PG:
6.1/III
ADR:
6.1/III
IMDG:
6.1/III
IATA:
6.1/III
WGK:
1
Storage:
RT
protected from light
Signal Word:
Danger
GHS Symbols:
GHS06
H Phrases:
H301
P Phrases:
P264
P301+P310
P321
P330
P405
P501
CS:
29419000
Download TDS file for complete specifications

Comments

Colistin was isolated from filtrates of Bacillus colistinus and is identical to Polymyxin E (mainly E1 and E2). It is a cyclic pentapeptide with a pentapeptide side chain. Colistin is active only against proliferating and non-proliferating gram negative organism. It interacts with phospholipids of the cytoplasmic membrane of bacteria and permeabilizes them. The efflux of essential components explains its bactericidal activity on non-proliferating organisms. The bactericidal activity will be reduced by divalent ions (Fe2\+, Mn2\+, Ca2\+, Mg2\+), unsaturated fatty acids and polyphosphates.Stability: A high stability is observed at pH values between 2 and 6. At pH values above 6.0, a slow inactiviation occurs (pH 9, 24 hours, 50 % inactivation). At pH 2, only 1 % will be inactivated within 24 hours. Solutions with a concentration of 10 mg/ml are stable at \+4°C for more than 10 - 14 days.