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Cycloheximide BioChemica

Assay (HPLC): min. 98 %
Code
A0879
CAS
66-81-9
Molecular Formula
C15H23NO4
Molar mass
281.36 g/mol

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Box prices only valid with purchase of full box.

code packaging size price per unit box price per unit
Code & packaging Price per piece
A0879,0001
code
A0879,0001
packaging size
1 g
price per unit
single $60,15
box price per unit
$51,13x 6 units
A0879,0005
code
A0879,0005
packaging size
5 g
price per unit
single $214,35
box price per unit
$182,20x 6 units
A0879,0025
code
A0879,0025
packaging size
25 g
price per unit
single $792,90
box price per unit
A0879,0100
code
A0879,0100
packaging size
100 g
price per unit
single $2730,75
box price per unit
A0879,0250
code
A0879,0250
packaging size
250 g
Product discontinued. Please check CAS-No. for alternative or contact our Customer Service.
Solubility:
21 g/L (H2O)
Physical Description:
Solid
Product Code:
A0879
Product Name:
Cycloheximide BioChemica
Specifications:
Assay (HPLC): min. 98 %
α20°C/D; 1 %, CHCl3: -26° - -32°
Comment:
Cycloheximide belongs to the group of the glutarimide antibiotics and has been isolated from Streptomyces griseus. It inhibits the binding of the aminoacyl-tRNA to the ribosomes, the transfer of amino acids from the aminoacyl-tRNA to the growing peptide chain and the release of the deacylated tRNA from the donor site of the ribosomes, as well as the translocation of the aminoacyl-tRNA from the acceptor site to the donor site of the ribosomes. The initiation of the peptide synthesis at reticulocyte ribosomes is stronger influenced, than the elongation of the peptide. The degradation and the reconstitution of polysomes is inhibited in several systems (1). The degradation of mRNA, as it has been shown for the c-fos mRNA, can be inhibited by cycloheximide, too (2). Inhibition of the protein biosynthesis leads, in the case of the so-called 'immediate early genes', to a superinduction by serum, with other words, to an increased transcription rate in response to the stimulus (3).Stability and solubility: Cycloheximide is watersoluble (2.1 g/100 ml at 2°C) or soluble in amyl acetate (7 g/100 ml). It is also soluble in chloroform, ether, acetone, methanol or ethanol. As a stock solution, prepare a filter-sterilized solution with a concentration of 10 mg/ml and store at -20°C. The working concentration is 10 μg/ml. Cycloheximide is rapidly inactivated at room temperature by diluted alkali. It is relatively heat-stable and acid-stable. Boiling at pH 7 for 15 minutes will not inactivate Cycloheximide, while boiling for one hour will destroy it. At pH 2 it is not destroyed by boiling for 1 hour.
Bibliography:
(1)Obrig, T.G. et al. (1971) J. Biol. Chem. 246, 174-181The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis in reticulocyte ribosomes. (2)Wilson, T. & Treisman, R. (1988) Nature 336, 396-399Removal of poly(A) and consequent degradation of c-fos - mRNA facilitated by 3' AU-rich sequences. (3)Subramaniam, M. et al. (1989) Nature 340, 64-66Negative regulation of serum-responsive enhancer elements.
Hazard pictograms
  • GHS06 Hazard
  • GHS08 Hazard
  • GHS09 Hazard
UN:
2811
Class/PG:
6.1/I
ADR:
6.1/I
IMDG:
6.1/I
IATA:
6.1/I
WGK:
3
Storage:
RT
Signal Word:
Danger
GHS Symbols:
GHS06
GHS08
GHS09
H Phrases:
H300
H341
H360D
H411
P Phrases:
P262
P280
P302+P352
P309+P311
EINECS:
200-636-0
CS:
29419000
Index Nr.:
613-140-00-8
Download TDS file for complete specifications