N-D-gluco-N-methylalkanamides are chemically analogous to alkyl glucosides. These nonionic detergents have a high CMC, are easily dialyzed, and have no absorbance at 280 nm (unlike NP40 or Triton X-100). Membrane dissolution does not denature membrane proteins (even at concentrations up to 20%), but does resolve protein-protein interactions. MEGA-8 is electrically neutral, does not interfere with ion pair chromatography and is compatible with various buffers.
(1) Hildreth, J.E.K. (1982) Biochem. J. 207, 363-366. N-D-Gluco-N-methylalkanamide compounds, a new class of non-ionic detergents for membrane biochemistry.