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Colistin Sulfate BioChemica

Assay (HPLC): min. 77 %
Code
A2922
CAS
1264-72-8
Molecular Formula
C53H104N16O21S2
Molar mass
1365.64 g/mol
Physical Description:
Solid
Product Code:
A2922
Product Name:
Colistin Sulfate BioChemica
Specifications:
Assay (HPLC): min. 77 %
pH (1 %; H2O): 4.0 - 6.0
Loss on drying: max. 3.5 %
Sulfate: 16 - 18 %
Comment:
Colistin was isolated from filtrates of Bacillus colistinus and is identical to Polymyxin E (mainly E1 and E2). It is a cyclic pentapeptide with a pentapeptide side chain. Colistin is active only against proliferating and non-proliferating gram negative organism. It interacts with phospholipids of the cytoplasmic membrane of bacteria and permeabilizes them. The efflux of essential components explains its bactericidal activity on non-proliferating organisms. The bactericidal activity will be reduced by divalent ions (Fe2\+, Mn2\+, Ca2\+, Mg2\+), unsaturated fatty acids and polyphosphates.Stability\: A high stability is observed at pH values between 2 and 6. At pH values above 6.0, a slow inactiviation occurs (pH 9, 24 hours, 50 % inactivation). At pH 2, only 1 % will be inactivated within 24 hours. Solutions with a concentration of 10 mg/ml are stable at \+4°C for more than 10 - 14 days.
Hazard pictograms
  • GHS06 Hazard
UN:
2811
Class/PG:
6.1/III
ADR:
6.1/III
IMDG:
6.1/III
IATA:
6.1/III
WGK:
1
Storage:
RT
protected from light
Signal Word:
Danger
GHS Symbols:
GHS06
H Phrases:
H301
P Phrases:
P264
P301+P310
P321
P330
P405
P501
CS:
29419000
Download TDS file for complete specifications