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D(+)-Galactose BioChemica, non animal origin

Assay (HPLC): min. 98 %
Code
A7983
CAS
59-23-4
Molecular Formula
C6H12O6
Molar mass
180.16 g/mol

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Box prices only valid with purchase of full box.

code packaging size price per unit box price per unit
Code & packaging Price per piece
A7983,0250
code
A7983,0250
packaging size
250 g
Product discontinued. Alternative A1131,0500 (please check specifications).
A7983,9025BW
code
A7983,9025BW
packaging size
25 kg
price per unit box price per unit
Solubility:
650 g/L (H2O)
Physical Description:
Solid
Product Code:
A7983
Product Name:
D(+)-Galactose BioChemica, non animal origin
Specifications:
Assay (HPLC): min. 98 %
α20°C/D; 10 %, H2O: +79.0° - +81.0°
Appearance of solution (H2O): clear, colorless
Melting range: 162 - 170°C
Sulfated ash: max. 0.10 %
Loss on drying: max. 0.3 %
Comment:
D-Galactose is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. In humans, absorption of galactose from food is mediated by Na/Glucose co-transporters. The monosaccharide is absorbed in the small intestine and catabolised in the liver. Galactose is converted through the Leloir pathway to galactose-1-phosphate, then to glucose-1-phosphate, and glucose-6-phosphate which can enter the glucose metabolism. Mutation of any of the enzymes of the conserved Leloir pathway can result in clinical deficiencies known as galactosemias. Research and applications: D-Galactose serves as substrate in enzyme studies (1, 2). Chronic D-Galactose exposure induces neurodegeneration in mice and Drosophila and has therefore been used as an aging model (3). Galactose might serve as a chaperone of alpha galactosidase and is therfore tested in treatments of the Fabry disease (4). The monosaccharide is used to some extend as a sweetener and dietary supplement. It is also used as an ultrasound contrast agent as the absorption by organs or tissues of the body is rather slow for certain preparations of Galactose.
Bibliography:
(1)Doudoroff, M. (1962) Methods Enzymol. 5, 339-341D-Galactose dehydrogenase from Pseudomonas saccharophila. (2)Dahms, A.S. & Anderson, R.L. (1972) J. Biol. Chem. 247, 2222-2227D-Fucose metabolism in a Pseudomonad. (3) Cui, X, Zuo, P, Zhang, Q, Li, X, Hu, Y, Long, J, Packer, L, Liu, J (2006) Journal of neuroscience research 84, 647-654 Constant exposure to D-galactose induces memory loss, neurodegeneration, and oxidative damage in mice; R-alpha-lipoic acid shows protective effects. (4) Okumiya et al. (1995) Biochem Biophys Res Commun. 214,1219-24 Galactose stabilizes various missense mutants of alpha-galactosidase in Fabry disease.
WGK:
nwg
Storage:
RT
EINECS:
200-416-4
CS:
29400000
Download TDS file for complete specifications