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D(+)-Galactose BioChemica

Assay (HPLC): min. 98 %
Code
A1131
CAS
59-23-4
Molecular Formula
C6H12O6
Molar mass
180.16 g/mol

Recommended prices only. For prices and orders please contact your local distributor.
Box prices only valid with purchase of full box.

code packaging size price per unit box price per unit
Code & packaging Price per piece
A1131,0100
code
A1131,0100
packaging size
100 g
price per unit
single $49,65
box price per unit
A1131,0500
code
A1131,0500
packaging size
500 g
Product active until stock lasts.
A1131,1000
code
A1131,1000
packaging size
1 kg
price per unit
single $305,40
box price per unit
molecule for: D(+)-Galactose BioChemica
Solubility:
650 g/L (H2O)
Physical Description:
Solid
Product Code:
A1131
Product Name:
D(+)-Galactose BioChemica
Specifications:
Assay (HPLC): min. 98 %
α20°C/D; 10 %, H2O: +78° - +81.5°
pH (10 %; H2O): 4.5 - 7.0
Heavy metals (as Pb): max. 0.001 %
Insoluble matter: passes test
Water (K.F.): max. 0.3 %
A (1 cm/0.1 M in H2O)
260 nm: max. 0.05
280 nm: max. 0.1
WGK:
1
Storage:
RT
EINECS:
200-416-4
CS:
29400000
Download TDS file for complete specifications

Comments

D-Galactose is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. In humans, absorption of galactose from food is mediated by Na/Glucose co-transporters. The monosaccharide is absorbed in the small intestine and catabolised in the liver. Galactose is converted through the Leloir pathway to galactose-1-phosphate, then to glucose-1-phosphate, and glucose-6-phosphate which can enter the glucose metabolism. Mutation of any of the enzymes of the conserved Leloir pathway can result in clinical deficiencies known as galactosemias. Research and applications: D-Galactose serves as substrate in enzyme studies (1, 2). Chronic D-Galactose exposure induces neurodegeneration in mice and Drosophila and has therefore been used as an aging model (3). Galactose might serve as a chaperone of alpha galactosidase and is therfore tested in treatments of the Fabry disease (4). The monosaccharide is used to some extend as a sweetener and dietary supplement. It is also used as an ultrasound contrast agent as the absorption by organs or tissues of the body is rather slow for certain preparations of Galactose.

Literature

(1) Doudoroff, M. (1962) Methods Enzymol. 5, 339-341. D-Galactose dehydrogenase from Pseudomonas saccharophila. (2) Dahms, A.S. & Anderson, R.L. (1972) J. Biol. Chem. 247, 2222-2227. D-Fucose metabolism in a Pseudomonad. (3) Cui, X, Zuo, P, Zhang, Q, Li, X, Hu, Y, Long, J, Packer, L, Liu, J (2006) Journal of neuroscience research 84, 647-654. Constant exposure to D-galactose induces memory loss, neurodegeneration, and oxidative damage in mice; R-alpha-lipoic acid shows protective effects. (4) Okumiya et al. (1995) Biochem Biophys Res Commun. 214,1219-24. Galactose stabilizes various missense mutants of alpha-galactosidase in Fabry disease.