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α-Amanitine BioChemica

Assay (HPLC): min. 95 %
Code
A1485
CAS
23109-05-9
Molecular Formula
C39H54N10O14S
Molar mass
918.98 g/mol
Physical Description:
Solid
Product Code:
A1485
Product Name:
α-Amanitine BioChemica
Specifications:
Assay (HPLC): min. 95 %
Hazard pictograms
  • GHS06 Hazard
  • GHS08 Hazard
UN:
3462
Class/PG:
6.1/II
ADR:
6.1/II
IMDG:
6.1/II
IATA:
6.1/II
WGK:
3
Storage:
2 - 8°C
Signal Word:
Danger
GHS Symbols:
GHS06
GHS08
H Phrases:
H300+H310+H330
H373
P Phrases:
P260
P301+P310
P320
P330
P361+P364
P405
P501a
Origin:
from Amanita phalloides
EINECS:
245-432-2
CS:
29339980
Download TDS file for complete specifications

Comments

The activity of RNA-Polymerase II is half-maximally inhibited by α-amanitine at 10-9 M, while RNA-Polymerase III requires much higher doses (10-5 - 10-4 M). RNA-Polymerase I is not sensitive at all. The LD₅₀ of the white mouse is 0.3 mg/kg.α-Amanitin is soluble in water, neutral buffer solutions (pH 6 - 8), ethanol, methanol, DMSO or dimethyl formamide. Store solutions at +4°C. The stability of an aqueous solution is 6 - 12 months and up to 2 years for solutions in alcohol, respectively.

Literature

(1)Brodner, O.G. & Wieland, T. (1976) Biochemistry 15, 3480-3484Identification of the Amatoxin-binding subunit of RNA-Polymerase B by affinity labeling experiments. Subunit B 3 - the true Amatoxin receptor protein of multiple RNA Polymerase B. (2)Wieland, T. (1983) Int. J. Peptide Protein Res. 22, 257-276Review article\: The toxic peptides from Amanita mushrooms.