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Amphotericin B BioChemica

Code
A1907
CAS
1397-89-3
Molecular Formula
C47H73NO17
Molar mass
924.10 g/mol

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Box prices only valid with purchase of full box.

code packaging size price per unit box price per unit
Code & packaging Price per piece
A1907,0050
code
A1907,0050
packaging size
50 mg
price per unit
single 28,00€
box price per unit
A1907,0001
code
A1907,0001
packaging size
1 g
price per unit
single 247,70€
box price per unit
A1907,9060
code
A1907,9060
packaging size
60 g
price per unit box price per unit
Physical Description:
Solid
Product Code:
A1907
Product Name:
Amphotericin B BioChemica
Specifications:
Activity: min. 750 I.U./mg
Solubility: clear, orange (10 %, DMF/1 M HCl 3 : 1)
Sulfated ash: max. 3 %
UV spectrum: passes test
Loss on drying (60°C; 0.7 kPa): max. 5 %
Amphotericin A: max. 15 %
Hazard pictograms
  • GHS07 Hazard
WGK:
3
Storage:
2 - 8°C
protected from light
Signal Word:
Attention
GHS Symbols:
GHS07
H Phrases:
H315
H319
H335
P Phrases:
P261
P280
P305+P351+P338
P403+P233
P405
P501
Origin:
from Streptomyces ssp.
EINECS:
215-742-2
CS:
29419000
Download TDS file for complete specifications

Comments

The antibiotic amphotericin B was isolated from Streptomyces nodosus. It belongs to the macrocyclic lactones and its action is fungistatic. Amphotericin B binds to sterols (e. g. cholesterol, cholestanol) with planar structure and disturbs the membrane permeability. Ions, like K\+, Na\+ and H\+ or other low molecular weight substances (e. g. amino acids, sugars, nucleotides) may cross the membrane (1). The cytotoxic concentration is approx. 30 μg/ml and the recommended working concentration at 2.5 μg/ml.Stability\: Amphotericin B is of low solubility in water at pH values from 6 - 7. At the pH 2 and 11, respectively, only 100 μg/ml can be dissolved. In DMSO, it is soluble at concentrations of 30 - 40 mg/ml, in propylene glycol 2 - 5 mg/ml, in acidified dimethyl formamide and acidic or alkaline methanol 60 - 80 mg/ml and 2 - 5 mg/ml, respectively. Store the dry substance protected from light and under argon. Under these conditions, the antibiotic is stable for more than 6 months. Aqueous solutions with a pH value of 5 - 7 are stable for 40 - 90 days, if stored at +4°C. Perform longer experiments protected from light, where possible, even if exposure to light for up to 8 hours has no negative influence. Amphotericin B is heat labile, but at 37°C it is stable for 3 days, nevertheless.

Literature

(1)Holz, R.W. (1979) Antibiotics V, p. 313 (F.E.Hahn ed.) Springer-Verlag Berlin, Heidelberg, New York. Polyene antibiotics\: Nystatin, Amphotericin B and Filipin. (2)Medoff, G. et al. (1983) Ann. Rev. Pharmacol. Toxicol. 23, 303-330Antifungal agents useful in therapy of systemic fungal infections. (3)Charak, B.S. et al. (1994) Br. J. Haematol. 88, 693-698Protecting effect of G-CSF against Amphotericin B-induced Myelosuppression in vitro.